What is Mesothelioma?
Mesothelioma is a form of
cancer that is almost always caused by previous exposure to
asbestos. In this disease,
malignant cells develop in the
mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the
pleura (outer lining of the
lungs and internal chest wall), but it may also occur in the
peritoneum (the lining of the abdominal cavity), the heart,
[1] the
pericardium (a sac that surrounds the
heart) or
tunica vaginalis.
Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or they have been exposed to asbestos dust and fiber in other ways. Washing the clothes of a family member who worked with asbestos can also put a person at risk for developing mesothelioma.
[2] Unlike lung cancer, there is no association between mesothelioma and
smoking.
[3] Compensation via asbestos funds or lawsuits is an important issue in mesothelioma (see
asbestos and the law).
The symptoms of mesothelioma include
shortness of breath due to
pleural effusion (fluid between the lung and the
chest wall) or chest wall
pain, and general symptoms such as
weight loss. The diagnosis may be suspected with
chest X-ray and
CT scan, and is confirmed with a
biopsy (tissue sample) and
microscopic examination. A
thoracoscopy (inserting a tube with a camera into the chest) can be used to take biopsies. It allows the introduction of substances such as
talc to obliterate the pleural space (called
pleurodesis), which prevents more fluid from accumulating and pressing on the lung. Despite treatment with
chemotherapy,
radiation therapy or sometimes
surgery, the disease carries a poor
prognosis. Research about
screening tests for the early detection of mesothelioma is ongoing.
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